Differential expression of cell adhesion molecule gene in abdominal aortic aneurysm
- VernacularTitle:腹主动脉瘤中细胞黏附分子差异表达的研究
- Author:
Hua CHEN
;
Yuehong ZHENG
;
Heng GUAN
;
Changwei LIU
;
Yongjun LI
;
- Publication Type:Journal Article
- Keywords:
Aortic aneurysm, abdominal;
Genes;
Adhesion molecules
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the differential expression of cell adhesion molecule(CAM) genes in the pathegenesis of AAA. Methods Microarray technique was applied to screen for the differential expression of CAM genes between AAA and normal aortic tissues. Results Three differentially expressed CAM genes were found in AAAs by microarray technique and molecular biology investigation, including VCAM 1, PECAM 1, TSP,with up regulating ratio of 5 683,3 601,57 406,respectively.Conclusion These abnormally up regulated CAM genes found in AAA might participate in the development of abdominal aortic aneurysms.
