bcl-2 and bad protein expression in breast carcinoma
- VernacularTitle:bcl-2和bad蛋白表达与乳腺癌的相关性研究
- Author:
Xiaowei WANG
;
Binglin GUO
;
Zhonghua SHANG
;
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Genes,bcl-2;
bad
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine gene bcl 2 and bad protein expression in tissues of breast cancer and precancerous lesions, its relation with estrogen receptor (ER) and progesterone receptor(PR), and lymph node metastasis.Methods Using immunohistochemical method, the expression of bcl 2 and bad gene were observed in 8 cases of normal breast tissues, 19 cases of simple breast hyperplasia, 20 cases of breast atypical hyperplasia and 48 cases of breast cancer. Results bcl 2 expression was positive in all normal breast tissues and simple hyperplasia, compared to 58 33% in breast cancer and 85 0% in atypical hyperplasia(all P
