Changes of angiogenesis in rectal cancer patients after preoperative radiotherapy
- VernacularTitle:术前放射治疗对直肠癌血管生成的影响
- Author:
Weisu LI
;
Fukun LIU
;
Zhonghao CHEN
;
Guiqin SUN
;
Jieshou LI
;
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Radiotherapy;
Microvessel density
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of preoperative radiotherapy on angiogenesis of rectal cancer. Methods Twenty patients with advanced lower rectal carcinoma received preoperative radiation with a dosage of 30～40 Gy each time for a total of 15～20 sessions during a period of 3～4 weeks. The definitive surgery was performed 7～10 days after radiotherapy. Another 20 patients undergoing tumor resection without preoperative radiotherapy served as control. Tumor sample was sent for pathology. The expression of vascular endothelial growth factor (VEGF) and CD34 in the rectal cancer were detected immunohistochemically. The intratumoral microvessel density (MVD) was measured. Results Fifteen patients were found with grade Ⅱ and five patients with grade Ⅲ tissue response in radiotherapy group. The diameter of intratumoral microvessel was smaller in radiotherapy group than in control group( P
