Expression of VEGF, HIF-1 alpha and EGF in hepatocellular carcinoma
- VernacularTitle:VEGF、HIF-1 alpha、EGF在肝细胞癌中的表达及其临床意义
- Author:
Gengwen HUANG
;
Lianyue YANG
;
Weiqun LU
;
Jianqing YANG
;
Heli LIU
;
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Neovascularization, pathologic;
Angiogenesis factor;
Epidermal growth factor-Urogastrone
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of vascular endothelial growth factor (VEGF) , hypoxia inducible factor 1 alpha (HIF 1?) and epidermal growth factor (EGF) in hepatocellular carcinoma (HCC) and their clinical significance. Methods The expressions of VEGF, HIF 1? and EGF in 36 cases of HCC and corresponding paraneoplastic tissues and normal liver tissues (6 cases) were studied by immunohistochemistry assay. ResultsThe expression rate of VEGF, HIF 1? and EGF in HCC tissue was 89%, 67% and 75% respectively, higher than those in paraneoplastic tissues and normal liver tissues ( P
