Clinical study of interrupting HBV intrauterine infection by immunization of pregnant women and infant
- VernacularTitle:孕妇及婴儿联合免疫阻断乙型肝炎病毒宫内传播的临床研究
- Author:
Guorong HAN
;
Minmin YU
;
Ling SHEN
;
Al ET
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Disease ttransmission,vertical;
Immunoglobulins,intravenous;
Hepatitis B vaccines;
Veccination
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of immunization combination of pregnant women and infants in preventing intrauterine HBV infection. Methods One hundred and twenty six HBsAg positive pregnant women were divided into two groups randomly.In the combination group,126 cases were injected with hepatitis B immunoglobulin(HBIG) during pregnancy since the 28 th week of gestation and HBVac 20 ?g at 1、2、7 month combining HBIG 200 IU at 0、15 day was injected to their infants, while 90 cases pregnant women in control group were not injected with HBIG. The serum HBV IgM of pregnant women and infant were tested using ELISA and was followed up for one year. Results The incidence of intrauterine HBV infection and the rate of chronic HBV infection in the infants of combination group were significantly lower than that of the control group (19.51% vs 35.56%, 13.33% vs 3.97% respectively). The detection rate of anti HBs in newborns and protective anti HBs in 1 year were significantly higher in combination group than that in the control group (80.95% vs 0,96.03% vs 86.67%). Conclusion Combining therapy of pregnant women and infant may prevent intrauterine HBV infection effictively and increase the rate of success immunoprophylaxis significantly, and decrease the rate of chronic HBsAg infection.
