Study on MTHFR gene and ACE gene polymorphisms in pregnancy-induced hypertension
- VernacularTitle:妊娠高血压综合征亚甲基四氢叶酸还原酶基因和血管紧张素转换酶基因多态性研究
- Author:
Dongwei MAO
;
Keshen LI
;
Yixuan ZHAO
;
Al ET
- Publication Type:Journal Article
- Keywords:
Amine oxidoreductases;
Peptidyl dipeptidase A;
Pregnancy complications, cardiovascular;
Hypertension;
Polymorphism (genetics)
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the methyenetetrahydrofolate (MTHFR) gene and angiotensin convertion enzyme (ACE) gene polymorphisms in pregnancy induced hypertension(PIH). Methods The MTHFR and ACE gene genotypes were determined in 62 pregnancy induced hypertension patients and 120 normal pregnant women by PCR RFLP. Results The frequencies of T allele(0.52) and the T/T genotype(27%) of MTHFR gene in PIH group were markedly higher than those in the control group(39% and 15% P