Relationship of c-erbB2 overexpression with endocrine therapy and prognosis in patients with breast carcinoma
- VernacularTitle:乳腺癌c-erbB2过表达与生存率、内分泌治疗效果和预后的关系
- Author:
Peng GAO
;
Gengyin ZHOU
;
Junmin WEI
;
Li LI
;
Yiran CAI
;
Miaoqing ZHAO
;
Chengjun ZHOU
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/genet;
ONCOGENES c erbB2;
GENE EXPRESSION;
BREAST NEOPLASMS/epidermiol;
SURVIVAL RATE
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of c erbB2 with endocrine therapy and prognosis, to investigate the rapid and effective method to detect c erbB2 alteration in breast carcinoma(BC).Metheds Semi quantitative PCR was used to detect the amplification of c erbB2, and immunohistochemistry was used to detect the expression of protein of c erbB2. 58 cases of BC were followed up .Results There was significant relationship between c erbB2 protein overexpression and gene amplification(P
