Effect of 5-fluorouracil on regulation of inflammation-associated cytokine in acute pancreatitis in rats
- VernacularTitle:5-氟尿嘧啶对大鼠急性胰腺炎炎症相关细胞因子的调节作用
- Author:
Xinfu FENG
;
Lingjun LU
;
Xiaoli CHEN
;
- Publication Type:Journal Article
- Keywords:
PANEREATITIS/physiopathol;
FLUOROURACIL/pharm;
INFLAMMATORY CYTOKINE/drug eff;
ANTI INFLAMMATORY CYTOKINE/drug eff;
PANCREAS/pathol
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of 5 fluorouracil (5 FU) on regulating the inflammatory and anti inflammatory cytokines in acute pancreatitis(AP) in rats, and to investigate the mechanism of treatment of AP with 5 FU. Method SD male rats were divided randomly into 3 groups:false operation group (n=6), AP group(n=24) and 5 FU treatment group(n=24). Then, AP group and 5 FU treatment group redivided respectively into 3 subgroups: After the AP model sut up or after 5 Fu treatment 2, 6 and 24 h subgroups (n=8). The animals were killed at the blood samples were taken for measurement of TNF ?, IL 1, IL 6, IL 10 and TGF ?. The wet weight of pancreatic tissue and blood amylase also were observed. Results Both serum inflammatory cytokines (TNF ?,IL 1 and IL 6) and anti inflammatory cytokines (IL 10 and TGF ?) in AP group increased significantly (P
