Monitoring of Serum Phenytoin Concentration in 130 Cases and Analysis of the Cases of Intoxication
- VernacularTitle:苯妥英血药浓度监测130例/次及中毒病例分折
- Author:
Wenjing QIAN
;
Shaogang SONG
;
Jianlong WU
;
Ying HE
;
Xiaoyan CHEN
;
- Publication Type:Journal Article
- Keywords:
phenytoin;
serum concentration of drug;
monitoring;
intoxication
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the relationship among the dosage, serum concentration and clinical effect of phenytoin(PHT) in treating epileptic patients .METHODS: 130 steady -- state serum concentrations of PHT were determined by fluores-cence polarization immunoassay(FPIA) in 70 patients with or without other drugs used in combination .RESULTS: The indi-vidual difference among the patients who received routine dosage of PHT was very significant. Intoxication occurred ex-tremely often in patients whose PHT serum concentrations were over 30?g/ml .CONCLUSION: It is necessary to perform TDM(Therapeutic Drug Monitoring) and individualize the use of PHT,so that the safe and effective use of drug can be ensured.
