Activity of Pyrazinamide Gel Against Mycobacterium Tuberculosis in Vitro and Eva luation of Its Security
- VernacularTitle:吡嗪酰胺介入凝胶体外抗结核活性及安全性评价
- Author:
Duanhao FENG
;
Hongmin LI
;
Minggui LIN
;
Yanjie XU
;
Yingchang SHI
;
Wei LIU
;
Hongzun LIU
;
Yuxuan GOU
;
Shan GOU
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Pyrazinamide;
gel;
antituberculotic;
intervention;
security
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the activity of Pyrazinamide gel against Mycob ac terium tuberculosis in vitro and its security in bronchial interventional therap y METHODS:The MIC and MBC of Pyrazinamide and Pyrazinamide gel were measured b y handwork method and instrument method and secuity of Pyrazinamide gel was asse ssed by bronchial interventional therapy in rabbits RESULTS:The MICs of pyrazi namide gel to M tuberculosis H37 RV,M bovis and M phlei were 1mg/L,1mg/L,1 0mg/L,the MBCs of Pyrazinamide gel to M tuberculosis H37RV,M bovis and M ph lei were 10mg/L,10mg/L,40mg/L respectively;the MIC and MBC of Pyrazinamide gel and those of Pyrazinamide had no significant differences;the animal security ex periment was negative CONCLUSION:These results suggest that Pyrazinamide gel a nd Pyrazinamide have the same efficacy against M tuberculosis,because carbomer dose not affect the activity of Pyrazinamide against M tuberculosis;Pyrazinami de gel which contains carbomer is safe in bronchial interventional therapy
