The expression of lung resistance protein gene (LRP) in hepatocellular carcinoma (HCC) and its clinical significance
- VernacularTitle:肝细胞癌肺耐药蛋白基因的表达及临床意义
- Author:
Bailin WANG
;
Xiaoping CHEN
;
Shuping ZHAI
;
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Genes, MDR
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the multidrug resistance (MDR) produced by lung resistance protein gene (LRP) in HCC, and the relationship between LRP and prognosis of HCC patients. Methods The expression of LRP encoding LRP and mRNA lrp was examined in the cancer tissue of 54 cases of previously untreated HCC, cancer adjacent liver tissue and liver biopsy of posthepatitic cirrhosis in 12 cases. The relationship between the expression of LRP and the change of AFP level in 24 posthepatectomy HCC cases was observed after receiving postoperative adjuvant chemotherapy in which the AFP had been positive. Results The positive rate of LRP and mRNA lrp was 61%, 33%, 17%, and 76%, 38%,33% respectively in three corresponding tissues, with significant difference between untreated HCC and two other tissues (CMH=4 27,6 71; P
