The expression of angiopoietin mRNA in hepatocellular carcinoma tissue and its relation with tumor angiogenesis and metastasis
- VernacularTitle:促血管生成素在肝癌组织中的表达与肝癌新生血管形成及转移的关系
- Author:
Lin PENG
;
Jian SUN
;
Weidong WANG
;
Jinrui OU
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Neovascularization, pathologic;
Neoplasm metastasis
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of angiopoietin in hepatocellular carcinoma tissue, and its relation with tumor angiogenesis and clinical significance. Methods Using immunohistochemistry and in situ hybridization, we observed the expression of angiopoietin 1(Ang 1) and angiopoietin 2(Ang 2) mRNA in 21 HCC patients and 5 normal liver tissues. The correlation between angiopoietin expression and several pathological markers was analyzed with computer statistical tools. Results Ang 1 equally expressed in tumor tissue, the adjacent noncarcinomatous tissue and normal liver. Ang 2 was highly expressed in tumor tissue, especially in tumor margin. The difference was significant between the group with metastasis and that without ( P
