Preoperative regional infusion chemotherpy for advanced breast cancer
- VernacularTitle:晚期乳腺癌术前局部灌注化疗的疗效观察
- Author:
Jianmiao HE
;
Yongdong PU
;
Zhiyu CAO
;
Bo YANG
;
Liguo DONG
;
Zhidong ZHU
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/drug ther;
INFUSIONS,INTRA ARTERIAL;
BREAST NEOPLASMS/pathol;
CARCINOMA,DUCTAL/durg ther
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathological and clinical effects of preoperative intra arterial infusion chemotherapy for patients with advanced breast cancer.Methods The clinical data of 52 patients with advanced breast cancer were analyzed retrospectively.Twenty two patients were treated with preoperative intra arterial infusion chemotherapy (treatment group),and 30 were treated without preoperative intra arterial infusion chemotherapy (control group).Results In the treatment group,the tumour size reduced and symptoms relieved after intra arterial infusion chemotherapy in 86.4% of the patients.Pathological examination of the specimens showed that raryopyknosis,raryorrhexis,cytoplasm coagulation and necrosis in cancer cells around the vascular vessels were found in all patients.Interstitial edema,inflammatory cells infiltration ,fibroelastosis around the cancer cells,proliferous intima thrombus and inflammation of vessels were also found.But in the control group,the histological chang of cancer cell was not found yet.All patients were followed up for 2 to 7 years.Local recurrence rate in the treatment group was 13.6%, while that of the control group was 33.3% (P
