Significance of smooth muscle differentiation in breast cancer stromal fibroblasts cells
- VernacularTitle:乳腺癌间质成纤维细胞的平滑肌分化及意义
- Author:
Yazhou CUI
;
Jingzhong SUN
;
Rong MA
;
Weidong ZHANG
;
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/pathol;
FIBROBLASTS/pathol;
MUSCLE,SMOOTH;
CARCINOMA,DUCTAL/pathol
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and assess the clinicopathological significance of smooth muscle differentiation in breast cancer stromal fibroblasts. Methods A monoclonal antibody recognizing ? smooth muscle actin was used to determine the smooth muscle differentiation of fibroblasts in 69 breast cancer(BC) tissues, compared with 8 breast tissues which were removed more than 5cm from the cancer margin comfirmed without cancer cells. The relationship between the smooth muscle differentiation and clinicopathological parameters including age, tumor size, lymph node metastatic status, histological grade and ER receptor status in invasive BC were analyzed. Results Stromal fibroblasts smooth muscle differentiation was defined in 55.0% of the invasive breast cancer tissues,whereas no immunostain was demonstrated in histological normal samples. Twenty eight of the 41 cases(68.3%) with matastatic lymph nodes showed stromal fibroblasts smooth muscle differentiation,which more than that of without lymphatic metastasis group (26.3%,P
