Expression of C-met protein and microvessel density in benign and malignant breast tissue and their clinical significance
- VernacularTitle:良恶性乳腺组织中Cmet蛋白表达和微血管密度的临床意义
- Author:
Jian GUO
;
Bo HUANG
;
Xiaofeng TIAN
;
Naiyu WANG
;
Haidong ZHAO
;
Ying LI
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/pathol;
MICROVESSEL DENSITY;
ONCOGENE PROTEIN C-met
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of C met protein and microvessel density (MVD) in benign and malignant breast diseases and the relation with the prognosis of the patients. Methods Expression of C met and MVD were detected by immunohistochemical SP method in the histologic sections of 20 benign hyperplasia patients and 70 breast cancer patients. Results Stain of C met was located in the membrane or cytoplasm of epithelia cells.In the benign breast hyperplasia, C met expression was 100%. The stain intensity in breast cancer was stronger than that in the benign hyperplasia, but not statistical significance. The expression of C met was higher in TNM stage Ⅲ cancer than that in stage ⅠandⅡcancer. The stronger expression of C met showed higher MVD and obviously lower survival rate . Coxregression indicated C met and microvessel were prognosis factors. Conclusions C met is expressed in benign and malignant breast disease, C met and MVD are related with survival rate of breast cancer patients , so they are valuable prognosis indicators of breast cancer patients.
