Significance and expression of nuclear factor-?B in human breast cancer
- VernacularTitle:核因子?B在人乳腺癌组织中的表达及其意义
- Author:
Gang TU
;
Zhenxiang YAO
;
Pujiang DONG
;
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/pathol;
NUCLEAR FACTOR ?B;
ONCOGENE PROTEIN p65
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and activation of nuclear transcription factor ?B(NF ?B) in human breast cancer (BC), and the relationship between the activity of NF ?B and malignant potential of BC. Methods The protein expression of NF ?B p65 in BC tissue and paratumor tissue were measured by Western blot; NF ?B DNA binding activity was examined by electrophoretic motility shift assay(EMSA)in 26 BC tissues and 12 paratumor tissues of BC.Results The levels of NF ?B p65 protein and NF ?B DNA binding activity in the tumor tissue were higher than those in the paratumor tissues(P
