Pendred's syndrome: a report of 5 cases
- VernacularTitle:Pendred综合征5例报告
- Author:
Jie HAN
;
Wei GENG
;
Yingbin CHANG
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
PENDRED'S SYNDROME;
CASE REPORT
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnosis and management of Pendred's syndrome. Methods The clinical data of 5 patients with Pendred's syndrome were analysed retrospectively. Results All patients had congenital sensorineural hearing loss and gradeⅡ-Ⅲ goiter,and 4 patients compained with thyroid nodure. Of the 5 cases, the results of perchlorate discharge test were 10%-52%. One case underwent subtotal thyroidectomy owing to misdiagnosis before the operation. All the 5 cases received thyroxine and were followed up for 4-7 years.All the patients goiter shrank and the compression symptoms relieved. Conclusions The perchlorate discharge test is the important diagnostic method and may detect the healthy carriers in the patients' relatives.Conservative treatment should be used in most patients. Patients undergoing operation owing to serious compression symptoms should be managed with thyroxine after surgery.
