Antiasthmatic Effect of Mabuterol in Guinea Pigs
- VernacularTitle:马布特罗对豚鼠的平喘作用研究
- Author:
Xueya WANG
;
Meihui WANG
;
Ji'An GUO
;
- Publication Type:Journal Article
- Keywords:
antiasthmatic;
Mabuterol;
bronchodilators;
? 2 -stimulant
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the antiasthmatic effect of Mabuterol in guinea pigs.METHODS:Severe dyspnea was induced by2%acetylcholine and0.1%histamine solution in conscious guinea pigs.RESULTS:Experiment showed that Mabuterol could significantly inhibit the experimental asthma induced by mixture of2%acetylcholine and0.1%histamine solution in conscious guinea pigs.It also significantly prolonged the latency of induced asthma and decreased the number of guinea pigs on twitches induced by asthma.Bronchodilating effect of Mabuterol was in a dose-dependent manner.The ED 50 of Mabuterol was0.2mg/kg and95%confidence limit was0.08～0.49mg/kg.CONCLUSION:In comparison with salbutanmol,Mabuterol is longer in duration and more potent in action of bronchodilatation.
