The basic mechanism of increased microvascular permeability
- VernacularTitle:血管通透性增高的基本机制
- Author:
Kesen ZHAO
;
Qiaobing HUANG
;
- Publication Type:Journal Article
- Keywords:
Vascular permeability;
Claudin;
Occludin;
Cadherins;
Stress fiber
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Theincreasedmicrovascularpermeabilityappearsmainlyinvenuleduringinflammation , shock ,andburns .Endothelialcellsplayanimportantroleinvenulepermeabilityenhancement.Therearetwo kindsofpathwayformacromoleculeextravasation .Oneisparacellularpathwayandanotheristranscellular pathway ,whicharerelatedtotheformationofendothelialgaportranscellularopeningsseperately .Thealter ationofintercellularrelatedprotein ,suchasoccludin ,claudin ,zonaoccludens (ZO) ,junctionaladhesion molecule (JAM) ,VE -cadherin ,catenin ,integrin ,etc ,andthealterationofendothelialcytoskeleton ,such asrearrangementofactinfilament,formationofstressfiberandfocaladhesion ,etc ,involveinthepathogenesis ofincreasedmicrovascularpermeability . [
