Proliferation and apoptosis of endothelia cells in cavernous hemangioma of the liver
- VernacularTitle:肝海绵状血管瘤内皮细胞凋亡与增殖活性的研究
- Author:
Jiantao JIANG
;
Guowei LI
;
Kangmin WANG
;
Shuangsuo DANG
;
Xijing WANG
;
Shiping ZHAO
- Publication Type:Journal Article
- Keywords:
LIVER NEOPLASMS/pathol;
HEMANGIOMA,CAVERNOUS/pathol;
APOPTOSIS;
CELL PROLIFERATION;
ENDOTHELIACELLS
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the proliferation and apoptosis of endothelia cells in cavernous hemangioma of liver(CHL),and to find their relation with the occurrence and development of CHL.Methods Twenty two CHL speciments of resection or biopsy in our hospital were collected.Another 10 speciments of small blood vessel in portal area of normal liver tissues and 10 speciments of strawberry hemangioma were collected as contrasts .The expression of proliferating cell nuclear antigen(PCNA) was assessed with monoclonal antibody of PCNA by immunohistochemical ABC method.The apoptosis of cells was assessed by end labeling method(TUNEL).Results Proliferation index(PI) of endothelia cells in CHL was 13.27?5.79.There wasn't significant difference from PI of endothelia cells of small blood vessels in portal aera of normal liver(10.85?4.79),while significant difference did exist compared with PI of tumor cells in strawberry hemangioma ( 29.31 ?8.55). Apoptosis index(AI) of endothelia cells in CHL was (3.49?1.36).There wasn't significant difference from AI of endothelia cells of small blood vessels in portal aera of normal liver(2.65?1.06),while significant difference did exist compared with AI of tumor cells in strawberry hemangioma ( 11.38 ?2.66,t=11.18,P
