Transplantation of microencapsulated xenogenic hepatocytes in treating fulminant hepatic failure in rats
- VernacularTitle:微囊化异种肝细胞移植对大鼠爆发性肝衰竭治疗作用的研究
- Author:
Anbin HU
;
Qichang ZHENG
;
- Publication Type:Journal Article
- Keywords:
LIVER TRANSPLANTATION;
TRANSPLANTATION,HETEROLOGOUS;
HEPATIC FUNCTION FAILURE;
HEPATECTOMY;
GRAFT REJECTION
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of microencapsulated xenogenic hepatocytes transplantation on rat fulminant hepatic failure(FHF).Methods Isolated guinea pig hepatocytes were microencapsulated with alginate-chitosan-polyethyleneglycol(ACP).The microencapsulated hepatocytes(MCHC) were implanted into the peritoneal cavity of Wister rats 24 hrs before the FHF model,which was surgically induced by 90% hepatectomy.After 24hrs of the FHF,the serum ALT,total bitirubin(TB),blood suger(BG) and PT were determined,and the microscopic appearance,function and nember of the implanted microencapsulated hepatocytes were observed,as well as the survival time and life quality of the FHF rats. Results Compared with the control group,the rats in the MCHC implantation group showed milder symptoms of central nervous system and less serious ascites.The ALT,BS, TB,and PT in the MCHC implantation group were all improved significantly (P
