Expression of CyclinD1 in gallbladder carcinoma and its relationship with clinlicopathological parameters
- VernacularTitle:CyclinD1在胆囊癌中的表达及其与临床病理因素的关系
- Author:
Yanming ZHOU
;
Youquan ZHU
;
Zuoliang XUE
;
Yumin LI
;
Nong CAO
;
- Publication Type:Journal Article
- Keywords:
GALLBLADDER NEOPLASMS/genet;
GENE EXPRISSION REGULATION,NEOPLASMS;
CYCLIND 1;
PCNA
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of CyclinD1 in gallbladder carcinoma and its relationship with clinlicopathological parameters.Method SABC immunohistochemistry was used to detect the expression of CyclinD1in 41carcinoma,15 chronic cholecystitis,10 normal tissue of gallbladder .Gallbladder carcinoma cell proliferation condition was detected by PCNA counting score .Results There were no positive signal of CyclinD1 deteted in chronic cholecystitis and in normal tissue,the positive rate of CyclinD1 in gallbladder carcinoma was 58.5%(24/41).The expression of CyclinD1 was related to tumor TNM stage, lymph node metastasis and cell differentiation (P
