Mechanism of 5-fluorouracil in the treatment of acute pancreatitis
- VernacularTitle:5-氟尿嘧啶治疗急性胰腺炎的机制探讨
- Author:
Rui DONG
;
Zifa WANG
;
Yi LU
;
Chengen PAN
;
Deming GAO
;
- Publication Type:Journal Article
- Keywords:
PANCREATITIS/drug ther;
FLUOROURACIL/ther use
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of 5 fluorouracil(5 FU) in the treatment of severe acute pancreatitis(SAP). Methods SD rats were randomly divided into three groups:acute pancreatitis group (AP group,n=12), 5 FU treatment group( 5 FU group,n=10),and control group (n=10). In 5 FU group,5 FU(1mg/100g) were injected immediately after AP was induced.12h after the AP was induced, blood samples were taken to determine nitric oxide(NO) and interleukin 6(IL 6). Results Compared with AP group,in 5 FU group, the survival rate increased,mean survival time prolonged,ascites volume decreased significantly,and the inflammatory mediators subsided. Conclusions NO and IL 6 may play an important role in the pathogenises of acute pancreatitis. The treatment effect of 5 FU for AP may through inhibit the inflammatory mediators.
