Protective effects of ischemia preconditioning and dexorubicin precondition ing on cryopreservation injury of ratlive
- VernacularTitle:缺血预处理和阿霉素预处理对大鼠肝脏低温保存损伤的保护作用
- Author:
Song QIN
;
Bei SUN
;
Jun XU
;
Yingjun TIAN
;
Hongchi JIANG
;
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Ischemic preconditioning;
Transplantation preconditioning
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTostudytheprotectiveeffectsofpreconditioningoncryopreservationinjuryofrat liver.MethodsThemodelofisolatednonrecirculatedperfusionratliver (IPRL)wasestablished .Thegrafts werepreconditionedwithischemia (IPC)anddexorubicin (DPC)respectively .ResultsThelevelsofaspartate transaminase (AST)andalaninetransaminase (ALT)inthesolutionsinIPCgroup (40 1? 6 3、17 1? 0 5 )U L andDPCgroup (43 6? 3 7、19 4? 0 8)U Lwerelowerthanthoseofnon preconditioning (NPC)group (6 4 5? 8 2、2 3 8? 3 96 )U L (P 0 0 5 ) .ConclusionsPreconditioninghasobviousprotectiveeffectsoncryopr eservationinjuryofratliver.MedicinepreconditioningmightimitatetheeffectofIPC .Medicinepreconditioning cansupplyclinicaltreatmentasasafeandeffectivepreconditioningmethod .
