Effect of bromocriptine on rats with experimental autoimmune uveoretinitis
- VernacularTitle:溴隐亭对大鼠实验性自身免疫性葡萄膜视网膜炎的影响
- Author:
Lei CHEN
;
Limin LIU
;
Zheli LIU
;
Jinsong ZHANG
- Publication Type:Journal Article
- Keywords:
Uveitis/drug therapy;
2 Bromoergocryptine/therapeutic use;
Animauls, laboratory
- From:
Chinese Journal of Ocular Fundus Diseases
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of bromocriptine on rats with experimental autoimmune uveoretinitis. Methods Tweenty four Wistar rats were immunized by bovine soluble antigen and randomly divided into treatment and control group. The rats in treatment group took bromocriptine orally with the dosage of 5 mg/(kg?d), which could inhibit prolactin (PRL) deliverance, while the rats in control group took glucose solution orally with the dosage of 50 g/(L?d). The clinical changes of all the rats and the delayed type hypersensitivity (DTH) response were detected. The rats were anesthetized and killed after immunized for 21 days, and the eyes were removed and examined histologically. Results The occurrence of EAU and histology scores of rats in treatment group were lower than the controls ( P 0.05). Conclusions Bromocriptine can generally inhibit PRL deliverance, and may also inhibit the occurrence of EAU in rats through neuroendocrine immune regulating network.
