Cellular Distribution of a-catenin in Epidermal Tumors
- VernacularTitle:表皮肿瘤细胞中?-连环蛋白的分布
- Author:
Xiang CHEN
;
Hongfu XIE
;
Qianjun DU
;
Mingliang CHEN
;
Fuwen CHEN
;
- Publication Type:Journal Article
- Keywords:
Carcinoma,squamous cell;
Carcinoma,basal cell;
Bowen′s disease;
a-catenin
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the cellular distribution and the role of a-catenin in epidermal tumors. Methods Expression of a-catenin was investigate d by immunohistochemical staining in 20 patients with Bowen′s disease (BD), 20 squamous cell carcinoma (SCC), 20 basal cell carcinoma (BCC), and 40 normal cont rols. Results Expression of a-catenin was strongest on the cell membranes of b asal cells, but nearly negative in the cytoplasm and the nuclei of epidermal cel ls in normal controls. Expression of a-catenin was significantly lower on the cell membranes in SCC and BCC cells than that in normal epidermal cells (P
