Expression of Desmoglein 1 and 2 in Different Epidermal Tumors
- VernacularTitle:桥粒芯糖蛋白1和2在不同表皮肿瘤中的表达
- Author:
Gangwen HAN
;
Zhanli TANG
;
Ping TU
;
Junyu ZHAO
;
Lingshen WU
;
Xuejun ZHU
- Publication Type:Journal Article
- Keywords:
Carcinoma,squamous cell;
Keratosis;
Keratoacanthoma;
Keratosis,se borrhoeic;
Desmoglein
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between desmosome-related proteins and epidermal tumors. Methods Using anti-desmoglein 1 and 2 monoclonal antibodies, expression of desmoglein 1 and 2 was examined by an immunohistochem ical staining method in various epidermal tumors such as squamous cell carcinoma (SCC), actinic keratosis(AK), keratoacanthoma(KA) and seborrhoeic keratosis(SK). Results Desmoglein 1 and 2 were strongly expressed in intercellular space of wh ole epidermis in normal human skin. Expression of desmoglein 1 and 2 was markedl y reduced or absent in SCC cells. Compared with normal epidermal cells, expressi on of desmoglein 1 and 2 was equal to or reduced,with complete absence of stain ing in dysplastic areas in AK cells. Extensive pericellur staining of desmoglein 1 and 2 was found in KA and SK cells, similar to that observed in normal epider mis. Conclusion Expression of desmoglein 1 and 2 is markedly reduced or absent i n human malignant epidermal cancers, reduction of these molecules may contribute to invasiveness and metastasis of epidermal carcinomas.
