Expression of Cell Cycle Related Factors Cyclin D1,CDK4,P16~(MTS1) and PRb in Condyloma Acuminatum
- VernacularTitle:细胞周期G1调节因子在尖锐湿疣皮损中的表达
- Author:
Fu DAI
;
Maorong ZHENG
;
Jin GUO
;
Yuchen XIE
;
Wenli LIU
;
Zhaoping LV
;
Li HE
;
Dongju SUN
;
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Cyclin D1;
Cyclin-dependent kinases;
Protein p16;
Retinoblas-toma protein
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and im plication of cell-cycle related factors(Cyclin D1,CDK4,P16 MTS1 and PRb)in condyloma acuminatum(CA).Methods The expression and distribution of cyclin D1,CDK4,P16 MTS1 and PRb were detected by immunohisto chemical technique streptavidin peroxidase(SP)in 27cases of HPV6/11positive CA that were confirmed by PCR and 10cases of norm al skins(foreskins).Results①Cyclin D1was not expressed in both normal skin and lesions of CA.②The intensity of expression of CDK4was 2.19in the basal cells in the lesions of CA,which was significantly weaker than that in normal skin(4.8,P
