Correlation between HLA gene and Takayasu arteritis in the Chinese
- VernacularTitle:国人HLA基因与多发性大动脉炎相关性研究
- Author:
Zhanxiang XIAO
;
Fuzhen CHEN
;
Haidong WANG
;
- Publication Type:Journal Article
- Keywords:
TAKAYASU ARTERITIS/genet;
GENE,HLA;
GENE FREQUENCY
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the correlation between HLA gene and Takayasu arteritis(TA) in the Chinese. Methods Forty four TA patients and 135 healthy controls were examined for HLA DQA 1 and HLA DQB 1 locus alleles by PCR/SSOP typing and mass genetics techniques. Results The frequency of DQA 1 0301 allele(14.8%) in TA patients was significantly decreased compared with the controls( 30.7% )(P0.05). Conclusions In Chinese, people with HLAⅡ DQB 1 0601 gene may be susceptible to TA, while people with HLAⅡ DQA 1 0301 gene may be resistant to TA.
