Relationship between Human Papillomavirus Infection and Expression of p16 in the Lesions of Condyloma Acuminata,Bowenoid Papulosis and Bowen's Disease
- VernacularTitle:尖锐湿疣、鲍温样丘疹病及鲍温病皮损中人乳头瘤病毒感染与P16蛋白表达的关系
- Author:
Shuping GUO
;
Liying CHEN
;
Li BAI
;
Yan FENG
;
- Publication Type:Journal Article
- Keywords:
Condylomataacuminata;
Bowenoidpapulosis;
Bowen'sdisease;
Papillomavirus,human;
Proteinp16
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveToinvestigatetheeffectofhigh-andlow-riskhumanpapillomavirus(HPVs)ontheexpressionofp16proteininthelesionsofcondylomaacuminata(CA),Bowenoidpapulosis(BP)andBowen'sdisease(BD).MethodsHPV6/11,HPV16/18DNAinthelesionswereexaminedwithFQ-PCRmethodin30casesofCAandinnormalskinormucosaof12cases.HPV16DNAweredetectedwithinsituhybridizationmethodin30casesofBPand15casesofBD.P16,Ki-67proteinswereexaminedwithimmunohistochemicalSPmethodinthesamespecimens.ResultsBothp16proteinandKi-67expressionwereincreasedinHPV-infectedlesions(P
