Impact of Metabolic Syndrome on the White Matter Integrity in Alzheimer's Disease Patients : Tract-Based Spatial Statistics Study under 3-Tesla MRI.
- Author:
Hwagyu SUH
1
;
Kangyoon LEE
;
Young Min LEE
;
Je Min PARK
;
Byung Dae LEE
;
Eunsoo MOON
;
Hee Jeong JEONG
;
Young In CHUNG
;
Ji Hoon KIM
;
Hak Jin KIM
;
Chi Woong MUN
;
Tae Hyung KIM
;
Young Hoon KIM
Author Information
1. Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
Metabolic syndrome;
White matter integrity;
Diffusion tensor imaging
- MeSH:
Alzheimer Disease*;
Anisotropy;
Busan;
Diffusion Tensor Imaging;
Education;
Humans;
Korea;
Magnetic Resonance Imaging*;
Memory;
Pyramidal Tracts;
White Matter*
- From:Journal of Korean Geriatric Psychiatry
2016;20(2):96-101
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The aim of this study is to determine whether there is any difference in white matter (WM) integrity between Alzheimer's disease (AD) with metabolic syndrome (MetS) and without MetS. METHODS: Altogether, 30 subjects were finally recruited from the Memory Impairment Clinics of Pusan National University Hospital in Korea. All subjects (AD with MetS : n=15, matched AD without MetS for age, gender and year of education : n=15) were underwent 3-tesla magnetic resonance imaging scans of diffusion tensor imaging. RESULTS: The mean fractional anisotropy of the AD with MetS was lower (p<0.05) in right posterior corona radiate, right corticospinal tract and right superior longitudinal fasciculus than that of the AD without MetS. CONCLUSION: Our findings suggest that WM integrity damage.
