Significance of fascin expression and the relationship to estrogen receptor in breast carcinoma
- VernacularTitle:成束蛋白在乳癌的表达及其与雌激素受体的相互关系和意义
- Author:
Weiqiang ZHENG
;
Jianming ZHENG
;
Jian LU
;
Fengxian HU
;
Chanrong NI
;
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/genet;
?RECEPTOR, ESTROGEN;
?BUNDING PROTEIN
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of fascin, an actin bundling protein associated with cell motility, and the relationship with ER negative breast carcinoma.Methods Comparasion of the expression of fascin, estrogen receptor (ER) and proliferative cell nuclear antigen (PCNA) determined by immunohistological method was made on 84 specimens of primary breast carcinomas. Results The diffuse staining of fascin in cancerous cell cytoplasm was noted. Only 3 of 53 breast carcinomas with ER positive showed fascin positive expression (5.67%); in contrast, 21 of 31 carcinomas with ER-negative showed positive expression(67.7 %) (P
