Influence of preoperative chemotherapy on telomerase activity in primary breast carcinoma
- VernacularTitle:抗癌药物术前化疗对乳癌端粒酶活性的影响
- Author:
Jianhua HUANG
;
Xingshen LU
;
Shaohua LIU
;
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/enzymol;
?TELOMERASE/metab;
?BREAST NEOPLASMS/drug ther;
?AMTINEOPLASTICDRUG, AGENTS COMBINED
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of preoperative chemotherapy (POCT) on telomerase activity(TA) of breast cancer and its mechanism. Methods TA was detected in 40 primary breast cancer specimens. Forty patients were divided into two groups: (1)POCT group. 32 patients, who underwent POCT using CMF scheme; (2) control group . 8 patients, who did not receive any POCT or radiotherapy. Results TA in POCT group(TA=0.499) was significantly lower than that in control group (TA=1.018). TA in patients received one , two or three times of POCT was 0.812,0.492 and 0.280 respectively. The difference of TA in patients received 1 time POCT and receive ≥ 2 times POCT was significant (P
