Significance of expression of p53 and p21 gene protein in breast cancer
- VernacularTitle:p53,p21在乳癌中的表达及意义
- Author:
Chunlin ZHAO
;
Feiyue WU
;
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/genet;
?ONCOGENE PROTEIN p53;
?ONCOGENE PROTEIN p21;
?GENE EXPRESSION
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical significance of the expression of p53, p21 protein in breast cancer (BC). Method The expression levels of p53, p21 proteins were examined by immunohistochemical (IHC) SP techniques in 69 BC specimen and 20 paracancinoma breast tissue. Result p53 and p21 proteins were failed to be observed in the paracancer tissue. p53 protein was found in 47.8% of BC, while p21 protein in 43.5% of BC. Along with the declined of BC cell differentiation degree, p53 expression increased significantly and p21 expression declined obviously. Expression of p21 was lower in patients with lymph node metastasis than that in patients without lymph node metastasis (P
