The effects of radix salviae miltiorrhiaze on the expression of Fas, perforin, and bcl-2 mRNA in liver ischemia with reperfusion
- VernacularTitle:肝门阻断再灌对肝组织Fas,穿孔素,bcl-2mRNA表达及丹参预处理的影响
- Author:
Qiping LU
;
Zaide WU
;
Xiaoping CHEN
;
Jingfeng LIU
;
- Publication Type:Journal Article
- Keywords:
REPERFUSION INJURY;
?LIVER/metab;
?PERFORIN;
FAS;
Bcl 2;
?RADIX SALVIAE MILTIORRHIAZE/pharmacol;
?LIVER/drug eff
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of radix salviae miltiorrhiaze(RSM) on the expression of Fas, perforin and bcl 2 mRNA in liver ischemia reperfusion(I R). Methods 45 patients were divided into three groups: Control group(group 1, n=5); I R group(group 2, n=20), and RSM pretreatment group(group 3, n=20). The patients in group 2 and group 3 subjected to hepatic resection with “Pringle procedure” for 15?min. Expression of Fas, perforin and bcl 2 mRNA were examined with reverse transcription polymerase chain reaction(RT PCR) after liver reperfusion for 40?min. Results Expression of Fas, perforin were very weak in control group(0.144?0.037; 0.106?0.032), but increased in group 2(0.928?0.135; 1.099?0.364); and in group 3 was significantly lower(0.347?0.081; 0.454?0.116)than that in group 2(P
