Clinical study on the effect of normothermic liver ischemic preconditioning on the expression of apoptosis regulating genes
- VernacularTitle:常温下缺血预处理对肝细胞凋亡调节基因表达影响的临床研究
- Author:
Guohuang HU
;
Xinsheng LU
;
- Publication Type:Journal Article
- Keywords:
LIVER/blood supply;
?ISCHEMIC;
?APOPTOSIS;
?REGULATING GENES EXPRESSION;
?REPERFUSION INJURY
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of apoptosis regulating genes C jun and bcl X L after normothermic liver ischemic preconditioning and its clinical significance. Methods 16 cases of liver cancer were randomly divided into ischemic reperfusion(IR) group and ischemic preconditioning (IP) group (8 cases in each). The samples of venous blood were drawn before IR or IP procedure and 30 minute after reperfusion for testing ALT, AST and LDH. Meanwhile, samples of liver tissue were taken for study of hepatocellular apoptosis, expressions of C-jun mRNA、 Bcl-X L mRNA and PCNA and morphologic changes. Results The levels of ALT、 AST、 LDH and AI in IR group were significantly higher than those in IP group (P
