The tumor-seeking specificity of [~(125)I]-(A14)-insulin in human hepatoma bearing nude mice
- VernacularTitle:[~(125)I]-(A14)单碘胰岛素在荷人肝癌裸鼠体内的趋瘤特性研究
- Author:
Yong DING
;
Qiulian WU
;
Hao XU
;
Chunyun WU
;
- Publication Type:Journal Article
- Keywords:
Insulin;
Radioisotopes;
Iodine;
Hepatoma;
Mice, nude
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe tumor-seeking specificity of [ 125 I]-(A14)-insulin in human hepatoma bearing nude mice METHODS: The in vivo tissue distribution and inhibition studies of [ 125 I]-(A14)-insulin in human hepatoma bearing nude mice were performed RESULTS: In the tissue distribution study, a significant accumulation of [ 125 I]-(A14)-insulin was observed in the tumor site of nude mice The tumor/blood and tumor/muscle radioactive ratio gradually increased with lengthening time following injection of [ 125 I]-(A14)-insulin The inhibition ratio in the tumor tissue of nude mice in the inhibition study was 35 0% CONCLUSION: There is a specific uptake of [ 125 I]-(A14)-insulin through receptor-mediated process in the hepatoma tissue of nude mice [
