Alternation of CEA levels in nude mice with liver metastases from colon cancer treated with ~ (131) I-labeled anti-CEA monoclonal antibody
- VernacularTitle:~(131)抗CEA单抗治疗结肠腺癌肝转移裸鼠对CEA水平影响的研究
- Author:
Haiyan GE
;
Guohua ZUO
;
- Publication Type:Journal Article
- Keywords:
COLON NEOPLASMS/ther;
ADENOCARCENOMA/ther;
RADIOIMMUNO THERAPY;
ANTIBODIES, MONOCONAL;
CEA/anal;
LIVERNEOPLASMS/second
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of CEA levels of blood, ascites and cancer tissue in nude mice with liver metastases from colon adenocarcinoma treated by 131 I labeled anti CEA monoclonal antibody (McAb). Methods 131 I labeled anti CEA McAb was injected through tail vein at 10min(early treatment group), 10d(middle treatment group) and 20d(late treatment group) after the liver metastases were established respectively. 131 I-labeled anti-normal mice IgG was injected through tail vein after the liver metastatic model was estabished as a control group. Results The CEA levels of blood, ascites and cancer tissue in early treatment group were significantly decreased compared with the control group (P0.05). Conclusions The CEA levels of blood, ascites and cancer nodulus in nude mice with liver metastases from colon cancer could be lowered significantly when the 131 I labeled anti CEA McAb is used early after the liver metastasis is established.
