Characteristics of morphology and left ventricular function in the mouse with myocarditis
- VernacularTitle:小鼠病毒性心肌炎的心肌结构及左室功能变化的初步研究
- Author:
Chaomin WAN
;
Zhengrong WANG
;
Mi ZHOU
;
Jianjun DENG
;
Taixiang WU
;
Hongji YU
- Publication Type:Journal Article
- Keywords:
Myocardial diseases;
Mitochondria, Heart;
Ventricular function, left;
Animals, laboratory
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To determine the relationship between microhistology and cardiac contractility in myocarditis animal model. METHODS:Setting up myocarditis animal model by injecting Coxsackivevirus B 3 (CVB 3) into mice, then observed myocardial morphological changes and measured left ventricular function of mice at the time of first three days and two weeks after injecting CVB 3.RESULTS:Subcellular structure (mitochondria) changed at the first three days after injecting CVB 3. The left ventricular pressure (LVP) and the rate of intraventricular pressure development (d p /d t ) which is the index of reflecting cardiac contractility depressed in this stage (14.2?0.8) kPa and (273.1?10.0)kPa/s, respectively. There were (17.1?0.7)kPa and (359.8?9.3)kPa/s in normal mice, respectively ( P
