Correlative study on changes of liver mitochondria calcium content and respiratory function in obstructive jaundice and biliary drainage
- VernacularTitle:胆道梗阻再通前后肝线粒体呼吸损害与钙含量变化的相关性研究
- Author:
Xuejun FANG
;
Yanbang CHI
;
Jing LI
- Publication Type:Journal Article
- Keywords:
Bile duct obstruction;
Biliary drainage;
Mitochondria;
Calcium;
Respiratory control rate;
Liver
- From:
Chinese Journal of Hepatobiliary Surgery
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the relationship between liver mitochondria calcium content and respi- ratory function in obstructive jaundice and biliary drainage.Methods The model of obstructive jaundice and bil- iary drainage was produced in dogs by common bile duct ligation and choledochoduodenostomy.The liver mitochon- dria were isolated and the calcium content and respiratory control rate were monitored.Results Mitochondria res- piratory control rate and calcium content significantly decreased and elevated respectively after bile duct ligation and there were varying degrees of recovery after biliary drainage,and the degree of recovery was evidently correlated with the duration of obstruction before drainage and the time after drainage.There was a strong negative correlation between the mitochondria calcium content and change of respiratory function.Conclusion The mitochondria cal- cium overload may be one of important factors for suppressed mitochondrial respiration in obstructive jaundice and early relief of the obstruction could favour the recovery of damaged liver mitochondria.
