Study on correlation between Child-Pugh grading and hepatic pathological changes
- VernacularTitle:Child-Pugh分级与肝脏病理改变的相关性研究
- Author:
Yu MAO
;
Kun LI
;
Folai CHEN
- Publication Type:Journal Article
- Keywords:
Hepatic cirrhosis;
Grading;
Pathology
- From:
Chinese Journal of Hepatobiliary Surgery
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the relationship between Child-Pugh grading and the degree of hep- atic cirrhosis.Method Six patients each with hepatic cirrhosis in Child-Pugh grade A and B were selected.The livers were observed with gross examinations during operation,and the liver specimens were observed with gross ex- aminations and also checked with light and electron microscopies.Results With naked eyes,it was quite difficult to find differences in size,shape and between different Child-Pugh grades.With hght microscopy,hepatic fibrosis of Ⅰ-Ⅱ degrees was commomly seen in Child-Pugh grade A and necrosis of hepatic cells was slight,while fibrosis of Ⅲ-Ⅴ degrees was usually found in grade B and necrosis was severe.With electron microscopy the collagen fib- rils in Disse's spaces were white cloud-like in grade A,while they were band-like in grade B.Of swelling and de- generation of organellae of hepatic and Kupffer cells,they were worse in grade B than in grade A.Conclusion The parameters in Child-Pugh grading are not complex,but they can be used to evaluate the degree of lesions. There is a positive relationship between them.
