Nuclear morphometry and PCNA analysis of adenoma and carcinoma in gallbladder
- VernacularTitle:胆囊腺癌和腺瘤细胞核形态学计量和PCNA定量分析
- Author:
Lin ZHANG
;
Shengquan ZOU
;
- Publication Type:Journal Article
- Keywords:
Gallbladder adenoma;
Malignant transformation of adenoma;
DNA ploidy;
PCNA
- From:
Chinese Journal of Hepatobiliary Surgery
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To make clear the relationship between adenoma,malignant transformation of ade- noma and carcinoma in gallbladder.Methodes The nuclear morphometry was performed with a TJTY-300 Auto- matic Image Analyser and PCNA was measured with immunohistochemisty in 25 cases of carcinoma,20 cases of adenoma and 3 cases of normal gallbladder.Results (1) Cell DNA content,atypia and PCNA index were in- creased gradually from the normal cell to dysplasia to malignant transformation of adenoma to carcinoma in gallblad- der;(2) Aneuploidy in gallbladder adenoma and PCNA index had significant relationship to the size of adenoma and gallstones (P
