Multivariate analysis of prognostic factors after radical resection for hepatocellular carcinoma
- VernacularTitle:肝细胞癌根治术预后的多因素分析
- Author:
Yue-Hua WANG
;
Yongxiong LIU
;
Yuquan FENG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Classification of radical resections;
Survival rate;
Disease-free survival rate
- From:
Chinese Journal of Hepatobiliary Surgery
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the prognostic factors after radical resection (RR) for hepatocellular carcinoma (HCC).Methods Altogether 144 patients who had undergone RR for HCC from 1988 through 1995 were included for a univariate and a Cox multivariate analysis.Nineteen factors contributing to overall survival rate (SR) and disease-free SR were analysed.Results The 5-year SR and disease-free SR (N=144) were 47.3% and 23.9%,separately.Multivariate analysis revealed that classification of RR was the signficant factor to overall SR,and presence of vessel invasion was the signficant factor to disease-free SR.The 5-year SR and disease-free SR in the patholngically RR and clinically RR groups were 60.2%,29.0% and 14.0%,0%,respectively.The 5-year disease-free SR in the group without (or with) vessel invasion was 27.8% (or 0%).Conclusions The classification of RR is the determinative prngnostie factor.Pathologically RR is the first option for patients with in- dications.It is essential to improve adjuvant therapy to decrease postoperative recurrence and metastasis rates.
