Inhaled Nitric Oxide at 44ppm Level Reverses Hypoxia-induced Pulmonary Vasoconstriction in the Newbron Rabbit Model
- VernacularTitle:吸入一氧化氮治疗新生兔急性低氧性肺动脉高压
- Author:
Jing SHEN
;
Renyu SUN
;
Jingzhen XU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Hypertension pulmonary;
Anoxia
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide laboratory data and direct experience of inhaling nitric oxide (NO) to treat persistent pulmonary hypertension of neonate.Methods Examined the effect of No on pulmonary arterial pressure of inhaled NO while rabbits were inhaled 44ppm NO,5% O_2 and air respectively in this model and those inspired air.Results Pulmonary hypertension was induced by reducing the fraction of inspired oxygen to 5% for 3 minutes.While 44ppm NO was added,a rapid decrease in pulmonary arterial pressure was observed (P
