Treatment Strategy after Endoscopic Resection of Superficial Esophageal Squamous Cell Carcinoma: A Single Institution Experience.
- Author:
Hyun Jik LEE
1
;
Hyuk LEE
;
Jun Chul PARK
;
Sung Kwan SHIN
;
Sang Kil LEE
;
Yong Chan LEE
Author Information
- Publication Type:Evaluation Studies ; Original Article
- Keywords: Endoscopic resection; Treatment strategy; Superficial esophageal squamous cell carcinoma
- MeSH: Aged; Aged, 80 and over; *Antineoplastic Protocols; Carcinoma, Squamous Cell/*pathology/*therapy; Chemoradiotherapy; Combined Modality Therapy; Dissection; Esophageal Neoplasms/*pathology/*therapy; Esophagectomy; *Esophagoscopy; Female; Humans; Male; Middle Aged; Mucous Membrane/pathology; Neoplasm Invasiveness; Neoplasm Recurrence, Local; *Postoperative Care; Postoperative Period; Retrospective Studies; Treatment Outcome; Tumor Burden
- From:Gut and Liver 2015;9(6):714-719
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The aim of this study was to analyze and propose a treatment strategy after endoscopic resection of superficial esophageal squamous cell carcinoma in a single institution. METHODS: This is a retrospective review of 37 patients who were treated by endoscopic resection during a 6-year period. RESULTS: The mean tumor size was 11.5+/-5.5 mm (range, 3 to 31 mm). Thirty-one lesions (83.8%) were treated by endoscopic submucosal dissection, and six lesions were treated by endoscopic mucosal resection (16.2%). The en bloc resection rate and complete resection rate were 91.9% and 81.8%, respectively. The tumor invasion depth was diagnosed as epithelial in five cases (13.5%), lamina propria mucosa in 12 cases (32.4%), muscularis mucosa in 10 cases (27.0%) and submucosa in 10 cases (27.0%). The complication rate was 13.5% and included three cases (8.1%) of perforation. Ten patients who had muscularis mucosa and submucosa lesions received additional treatments, including six patients who were treated with esophagectomy, three patients who were treated with radiotherapy and one patient who was treated with chemoradiotherapy. One patient with lamina propria lesions received radiotherapy due to a positive resection margin. The median follow-up duration was 22 months (range, 4 to 79 months), and no recurrence or metastasis was noted during follow-up. CONCLUSIONS: Tailored management after endoscopic treatment of superficial esophageal squamous cell carcinoma can offer an acceptable oncologic outcome in early esophageal carcinoma.
