Comparison of etomidate in lipid emulsion and propylene glycol during induction of anesthesia
- VernacularTitle:比较两种制剂依托咪酯在麻醉诱导中的作用
- Author:
Wenyao CUI
;
Junke WANG
;
Zhuoren SHENG
;
- Publication Type:Journal Article
- Keywords:
Etomidate;
Pain;
Injections,intravenous;
Phlebitis;
Thrombophlebitis
- From:Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare etomidate in propylene glycol(Eto-PG) with a new galenic preparation of etomidate solved in a lipid emulsion of soya-bean oil(Eto-Lip).Method:Sixty patients were randomly divided into 2 groups:Eto-PG group and Eto-Lip group.The dosage of etomidate was 0.3mg/kg.Hemodynamic change and side effects(pain on iv-injection,involuntary movement, phlebitis, thrombophlebitis etc.) were observed.Result:There were no difference between the two groups in the incidence of involuntary movement.Side effects at the site of injection,both immediate and after operation,were encountered with Eto-PG but were not encountered in the lipid emulsion. Conclusion:Eto-Lip can reduce some undesired side effects without changing its pharmacodynamics.
