Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study.
- Author:
Ki Nam SHIM
1
;
Eun Mi SONG
;
Yoon Tae JEEN
;
Jin Oh KIM
;
Seong Ran JEON
;
Dong Kyung CHANG
;
Hyun Joo SONG
;
Yun Jeong LIM
;
Jin Soo KIM
;
Byong Duk YE
;
Cheol Hee PARK
;
Seong Woo JEON
;
Jae Hee CHEON
;
Kwang Jae LEE
;
Ji Hyun KIM
;
Byung Ik JANG
;
Jeong Seop MOON
;
Hoon Jae CHUN
;
Myung Gyu CHOI
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Anti-inflammatory agents; non-steroidal; Capsule endoscopy; Outcome
- MeSH: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal/*adverse effects; Aspirin/adverse effects; *Capsule Endoscopy; Female; Humans; Intestinal Diseases/chemically induced/*pathology; Intestine, Small/*drug effects/injuries/*pathology; Male; Middle Aged; Recurrence; Republic of Korea; Retrospective Studies; Time Factors; Ulcer/chemically induced/*pathology
- From:Gut and Liver 2015;9(6):727-733
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). METHODS: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. RESULTS: A total of 140 patients (87 males; mean age, 60.6+/-14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9+/-19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence. CONCLUSIONS: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.
