Tumor necrosis factor-? mediates acid aspiration-induced acute lung injury
- VernacularTitle:TNF-?介导酸误吸引起的急性肺损伤
- Author:
Xin LIU
;
Jinpu YU
;
Haibo HUANG
;
- Publication Type:Journal Article
- Keywords:
Acid aspiration;
Tumor necrosis factor-?;
Malondialdehyde;
Verapamil;
Vitamin C
- From:
Chinese Journal of Anesthesiology
1996;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To test the role of tumor necrosis factor-?(TNF-?)in acute lung injury and study new treatment.Method:The rabbit acid aspiration models were induced with 0.1N hydrochloric acid (HCI). Twenty rabbits were divided randomly into HCl group,verapamil and vitamin C groups.The plasma levels of TNF-? and malondialdehyde (MDA) were measured,and polymorphonuclear neutrophils (PMN)were counted in lung tissue of all animals. Result:There were increases in TNF-?,MDA and PMN after acid aspiration,which can be inhibited by verapamil and vitamin C. Conclusion:PMN can be induced by TNF-?.Vitamin C and verapamil provide a obvious protection on pulmonary tissue after acid aspiration.
