The Role of Prostaglandin E_2 on Pathogenesis of Candidal Vaginitis
- VernacularTitle:前列腺素 E_2在念珠菌性阴道炎发病机理中的作用
- Author:
Xiaohong LEI
;
Qingyi YE
;
Zhiming CAO
;
- Publication Type:Journal Article
- Keywords:
Candidal vaginitis;
Candida albicans;
Prostaglandin E2
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the role of prostaglandin E2(PGE_2)on the pathogenesis of candidal vaginitis,the effect of Candida albicans and histamine on the production of PGE_2 by peripheral blood mononuclear cells from patients with candidal vaginitis and normal controls,the effect of PGE2 on germ tube formation of Candida albicans,and the effect of PGE2 on Candida albicans adhering to vaginal ep- ithelial cells were observed.The results showed that:Candida albicans and histamine induced PGE2 synergistically,and the production of PGE2 increased markedly.PGE2 enhanced germ tube formation in Candida albicans,increased the number of Candida albicans adhering to the vaginal epithelial cells, and the pathogenicity of C.albicans.The above results indicate that PGE_2 plays a role in the pathogene- sis of candidal vaginitis.
