Study on the Induction of Skin Cancer by Coal Tar Pitch Smoke in Mice
- VernacularTitle:煤焦沥青烟气诱发小鼠皮肤癌的实验研究
- Author:
Ying WANG
;
Shuling ZHANG
;
Jiang WANG
;
- Publication Type:Journal Article
- Keywords:
Pitch;
Cancer,skin
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study,100 mice were divided into two groups(group A and B)to study the car- cinogenic effect of pitch smoke on skin.Mice in group A were exposed to coal tar pitch smoke(CTPS) 3 hours a day in a box 6 days per week.The average concentration of CTPS in the box was 0.17mg/L. The duration of exposure was 4 months.These mice were followed up for another 4 months.Group B was designed as a control.After eight months,skin neoplasms were found in 40 mice(83.33%)in group A,of which squamous cell carcinomas were found in 32 mice(66.67%).Lymph node metastasis of the carcinoma was found in 8 mice.No skin tumor was found in group B.The result of present study shows that CTPS has strong carcinogenic effect on skin.
